recent publications

03 — Publications

Recent peer-reviewed work and working papers spanning adaptive and biologically informed radiotherapy, optimization, longitudinal biomarkers, cardio-oncology, medical imaging, and clinical decision-making.

Working papers & preprints

Manuscripts currently under review, in revision, or available as preprints. Published versions are moved to the peer-reviewed record below.

Incorporating Neoadjuvant Immunotherapy Response in Post-Operative Head and Neck Squamous Cell Carcinoma Radiation Therapy Planning

Fattahi S, Buti G, Beekman C, Minken J, Mukundan D, Xie Y, Dexter H, Ferguson D, Bortfeld T, Schoenfeld J*, Ajdari A*

submitted to Radiotherapy and Oncology · 2026

Addressing data- and biomarker-driven uncertainty in machine-learning-based outcome predictions in radiotherapy

Buti G, Bondi, A, Lomax A, Liao Z, Bortfeld T, Ajdari A

working paper · 2026

A hybrid optimization framework provides new pathways for inverse planning with machine-learning NTCP models

Ortkamp T, Leininger F, Liao X, Wahl N, Ajdari A

under revision in Frontiers in Oncology · 2026

Dynamic prediction of radiation-induced cardiac arrhythmia for after non-small cell lung cancer radiotherapy

Salome P, Bobic M, Ciausu C, Guthier C, Jimenez R, Keane F, Ajdari A

working paper · 2026

Optimizing Liver Radiotherapy Against Individual Predicted Toxicity Risk

Ajdari A, Wo J, Hong T, Chamseddine I

working paper · 2026

2026

Parametric delineation of the clinical target volume for glioma: Model-based approach that tailors to physician contouring practices

Buti G, Ajdari A, Bridge C, Marciscano AE, Sharp GC, et al.

Radiotherapy and Oncology · 2026

Target definition Model-based planning Imaging

Escalation of resting heart rate and tachycardia as a response to thoracic radiotherapy: implications for cardiovascular outcomes after radiotherapy

Ajdari A, Bobic M, Ciausu C, Cooper A, Guthier C, Neilan TG, Bortfeld T, Willers H, Jimenez RB, Keane FK

International Journal of Radiation Oncology Biology Physics · 2026

Cardio-oncology Longitudinal biomarkers Thoracic RT

Integrating biomarker-derived individual treatment response assessment into Bayesian trial design for personalized cancer treatment

Kolias P, Ajdari A, Cicchetti A, Jeraj R, Toma-Dasu I, Thorwarth D, Gani C, Thieke C, Nicolay NH, Fiorino C, Bortfeld T, Niyazi M

Radiotherapy and Oncology · 219 · 111484

Biomarkers Personalization

Bi-level multi-criteria optimization for risk-informed radiotherapy

Schubert M, Teichert K, Bortfeld T, Liao X, Ajdari A

Physics in Medicine & Biology · 71 · 135037

Optimization Risk-informed RT

Probabilistic clinical target definition with nearest neighbor correlation

Rivetti L, Buti G, Amoudruz L, Ajdari A, Sharp G, Studen A, Jeraj R, Bortfeld T

Physics in Medicine & Biology · 71(1)

Target definition Probabilistic modeling

2025

Bayesian learning to reduce cardiac risk of patients with locally advanced non-small cell lung cancer based on personalized radiation therapy prescription

Lin R, Chen M, Zhang X, Xu T, Maguire RC, Corrigan KL, Koutroumpakis E, Chang JY, Lin SH, Chen AB, Nguyen QN, Gandhi SJ, Ning MS, Bronk J, Chun S, Ajdari A, Niedzielski JS, Yang J, Chen X, Pan T, Meng QH, Tsao AS, Deswal A, Mohan R, Liao Z

International Journal of Radiation Oncology Biology Physics · 2025

Cardiac risk Bayesian learning

Radiation doses to cardiac substructures predict elevation in high-sensitivity cardiac troponin T levels in radiation therapy for lung cancer

Chen X, Zhang X, Xu T, Mohan R, Lin R, Chen M, Maguire RC, Zhao Y, Koutroumpakis E, Palaskas NL, Deswal A, Ajdari A, Niedzielski JS, Shete SS, Court LE, Yang J, Liao Z

International Journal of Radiation Oncology Biology Physics · 2025

Cardio-oncology Dosimetry

Clinical target volumes for glioma — automated delineation to improve neuroanatomic consistency

Buti G, Giovenco M, Yilmaz T, Ajdari A, Bridge CP, Sharp GC, Löfman F, Shih HA, Bortfeld T

Physics and Imaging in Radiation Oncology · 36 · 100865

Imaging Target definition

Chebyshev-polynomial-based deformable registration of magnetic resonance images with a specific application in adaptive gantry-less proton therapy

Kim H, Hickey S, Buti G, Ajdari A, Sharp GC, Yan S, Bortfeld T

Physics in Medicine & Biology · 70(19)

Imaging Adaptive RT

Investigating the potential of diffusion tensor atlases to generate anisotropic clinical tumor volumes in glioblastoma patients

Hochreuter K, Buti G, Ajdari A, Bridge CP, Sharp GC, Jespersen S, Lukacova S, Bortfeld T, Kallehauge JF

Physics and Imaging in Radiation Oncology · 33 · 100688

Imaging

2024

Diffusion tensor transformation for personalizing target volumes in radiation therapy

Buti G, Ajdari A, Bridge CP, Sharp GC, Bortfeld T

Medical Image Analysis · 97 · 103271

Imaging Personalization

Integrating muscle fiber orientation from visible human data into radiotherapy target volumes

Buti G, Ajdari A, Chen YL, Bridge CP, Sharp GC, Bortfeld T

Physics in Medicine & Biology · 69(14)

Imaging

A reference-point-method-based online proton treatment plan re-optimization strategy and a novel solution to planning constraint infeasibility

Qiu Z, Depauw N, Gorissen BL, Madden T, Ajdari A, den Hertog D, Bortfeld T

Physics in Medicine & Biology · 69(12)

Optimization Adaptive RT

Embedding machine-learning-based toxicity models within radiotherapy treatment-plan optimization

Maragno D, Buti G, Birbil SI, Liao Z, Bortfeld T, den Hertog D, Ajdari A

Physics in Medicine & Biology · 69(7)

Optimization Machine learning

The influence of anisotropy on the clinical target volume of brain tumor patients

Buti G, Ajdari A, Hochreuter K, Shih H, Bridge CP, Sharp GC, Bortfeld T

Physics in Medicine & Biology · 69(3)

Imaging