Boston, MA

Ali Ajdari, PhD

Instructor in Radiation Oncology, Harvard Medical School · Massachusetts General Hospital · Mass General Cancer Institute
Ali Ajdari

My research asks a simple question: what if cancer treatment could learn from the patient as it unfolds? I develop computational methods that combine mathematical optimization, artificial intelligence, and longitudinal patient data to turn evolving treatment response into better clinical decisions — while there is still time to act.

Longitudinal treatment response observe → predict → intervene
Longitudinal patient response informing treatment adaptation Patient measurements are collected over time, interpreted through predictive models, and used to trigger a treatment adaptation that changes the subsequent response trajectory. TREATMENT START FOLLOW-UP MONITOR PREDICT PERSONALIZE DELIVER LONGITUDINAL DATA DECISION POINT updated risk + predicted response WITHOUT ADAPTATION Δ ADAPT TREATMENT
01 · Monitor
Measure response

Longitudinally extract clinically meaningful signals from radiological imaging, molecular assays, wearables, and clinical data.

02 · Personalize
Adapt treatment

Use prediction and optimization to determine when treatment should change, and how it should change for an individual patient.

03 · Deliver
Improve access

Build decision-support and operations research tools that make advanced cancer care more efficient, deployable, and accessible across care spectrurm.

Current work

From methods to clinical systems.

Digital health . biomarker study Active

Digital biomarker-assisted cardiovascular monitoring

Longitudinal physiological monitoring during and after radiotherapy using wearable-derived cardiovascular biomarkers.

Machine learning Active

Dynamic cardiovascular risk prediction & intervention

Integrating evolving heart-rate dynamics and cardiac dosimetry to identify risk during treatment and inform potential adaptation.

mathematical optimization Active

Bi-level optimization for biologically informed radiotherapy

Embedding predictive models and biological objectives within clinically interpretable treatment-plan optimization.

operations research ACTIVE

Optimization for radiation oncology access

Decision-support for patient scheduling, machine allocation, capacity utilization, and timely access to radiation therapy.

Recent publications

Selected recent work.

2026
Parametric delineation of the clinical target volume for glioma: Model-based approach that tailors to physician contouring practices
Radiotherapy and Oncology
2026
Escalation of resting heart rate and tachycardia as a response to thoracic radiotherapy
International Journal of Radiation Oncology · Biology · Physics
2026
Bi-level multi-criteria optimization for risk-informed radiotherapy
Physics in Medicine & Biology
Explore
Radiation oncology · computational oncology · mathematical optimization · longitudinal biomarkers · clinical decision support